Before you start to enlarge your Instagram profile picture, choose a high quality picture. An image with clear outlines and a central point of focus works best. Make sure the image is well lit and represents your personality or brand well. There are various online tools that can help you enlarge your Instagram profile picture without sacrificing quality. Upload your chosen image to one of these tools and resize accordingly. Make sure the image still remains clear and sharp as it is enlarged. Once you have the image the size you want, save it to your device. Make sure the image is saved in JPG or PNG format to ensure the best quality.